Angiotensin Converting Enzyme Inhibitor and ApoE4 on Alzheimers disease        
  
   Lead Investigator:    Wendy Wei Qiao Qiu
   Institution      :    Boston University School of Medicine
   E-Mail           :    wqiu67@bu.edu
   Proposal ID      :    163



   Proposal Description:
   Since ACE inhibitor inhibits Abeta degradation and the ACE inhibitor treatment    on APP transgenic mice result conflicting results on the AD pathology, we aim     to study the relationship between ApoE4, ACE inhibitor and AD by using the ADC    longitudinal data. We hypothesize that the impact of ACE inhibitor on AD will     be different between those with and without ApoE4 allele.